Inhibition and reversal of a TGF-β1 induced myofibroblast phenotype by adipose tissue-derived paracrine factors.
S HigginbothamV L WorkmanA-V GiblinNicola Helen GreenDaniel W LambertVanessa L HearndenPublished in: Stem cell research & therapy (2024)
Cultured ADSC or adipocytes have been the focus of most studies, however, this work highlights the importance of considering whole adipose tissue to further our understanding of fat grafting. This study supports the use of autologous fat grafts for scar treatment and highlights the need for further investigation to determine the mechanism.
Keyphrases
- adipose tissue
- insulin resistance
- high fat diet
- transforming growth factor
- high glucose
- endothelial cells
- bone marrow
- cell therapy
- stem cells
- epithelial mesenchymal transition
- drug induced
- mesenchymal stem cells
- wound healing
- metabolic syndrome
- case control
- platelet rich plasma
- oxidative stress
- fatty acid
- high fat diet induced
- stress induced