Metformin Disrupts Bile Acid Efflux by Repressing Bile Salt Export Pump Expression.

Brandy GarzelTao HuLinhao LiYuanfu LuScott HeywardJames PolliLei ZhangShiew-Mei HuangJean-Pierre RaufmanHongbing Wang

Published in: Pharmaceutical research (2020)

Repression of BSEP alone is sufficient to disrupt hepatic bile acid efflux. Metformin and tamoxifen appear to be prototypes of a class of BSEP repressors that may cause drug-induced cholestasis through gene repression instead of direct BSEP inhibition.

Keyphrases

drug induced
liver injury
poor prognosis
copy number
genome wide
adverse drug
breast cancer cells
estrogen receptor
positive breast cancer
genome wide identification
gene expression
dna methylation