The citrus flavanone naringenin attenuates zymosan-induced mouse joint inflammation: induction of Nrf2 expression in recruited CD45+ hematopoietic cells.

Allan J C BussmannSergio M BorghiTiago H ZaninelliTelma S Dos SantosCarla F S GuazelliVictor FattoriTalita P DomicianoFelipe A Pinho-RibeiroKenji W Ruiz-MiyazawaAntonio M B CasellaJosiane A VignoliDoumit Camilios-NetoRubia CasagrandeWaldiceu Aparecido Verri

Published in: Inflammopharmacology (2019)

Naringenin presents analgesic and anti-inflammatory effects in zymosan-induced arthritis by targeting its main physiopathological mechanisms. These data highlight this flavonoid as an interesting therapeutic compound to treat joint inflammation, deserving additional pre-clinical and clinical studies.

Keyphrases

oxidative stress
diabetic rats
induced apoptosis
high glucose
poor prognosis
rheumatoid arthritis
bone marrow
cell cycle arrest
spinal cord
endoplasmic reticulum stress
big data
spinal cord injury
long non coding rna
cell proliferation
cell death
signaling pathway
artificial intelligence