Association of rs2062323 in the TREM1 gene with Alzheimer's disease and cerebrospinal fluid-soluble TREM2.

Zuo-Teng WangYan FuShi-Dong ChenYu-Yuan HuangYa-Hui MaYan-Jiang WangLan TanJin-Tai Yu

Published in: CNS neuroscience & therapeutics (2023)

This study is the first to identify significant associations between TREM1 rs2062323 and AD risk. The rs2062323T may be involved in AD by regulating the expression of TREM1, TREML1, TREM2, and sTREM2. The TREM family is expected to be a potential therapeutic target for AD.

Keyphrases

cerebrospinal fluid
poor prognosis
gene expression
dna methylation
binding protein
long non coding rna
genome wide identification