Human predecidual stromal cells are mesenchymal stromal/stem cells and have a therapeutic effect in an immune-based mouse model of recurrent spontaneous abortion.

Raquel Muñoz-FernándezClaudia De La MataFrancisco RequenaFrancisco MartínPablo Fernandez-RubioTatiana LlorcaMaria José Ruiz-MagañaCarmen Ruiz-RuizEnrique G Olivares

Published in: Stem cell research & therapy (2019)

Together, our results confirm that preDSCs are decidual MSCs and suggest that these cells are involved in the mechanisms of maternal-fetal immune tolerance.

Keyphrases

stem cells
mouse model
bone marrow
induced apoptosis
endothelial cells
cell cycle arrest
mesenchymal stem cells
induced pluripotent stem cells
cell death
pluripotent stem cells
oxidative stress
signaling pathway
umbilical cord
pregnancy outcomes
body mass index
physical activity
pi k akt