Impaired Interleukin-18 Signaling in Natural Killer Cells From Patients With Systemic Juvenile Idiopathic Arthritis.

Takashi OhyaKenichi NishimuraAyako MuraseSeira HattoriAsami OharaTomo NozawaRyoki HaraShuichi Ito

Published in: ACR open rheumatology (2022)

Impaired IL-18 signaling in NK cells correlated with disease activity in sJIA. High serum IL-18 exposure induces impaired MAPK and NFκB phosphorylation in NK cells.

Keyphrases

nk cells
juvenile idiopathic arthritis
disease activity
rheumatoid arthritis
systemic lupus erythematosus
natural killer cells
rheumatoid arthritis patients
signaling pathway
ankylosing spondylitis
oxidative stress
pi k akt
lps induced
immune response
drug induced
protein kinase