Intragenic DNA methylation of PITX1 and the adjacent long non-coding RNA C5orf66-AS1 are prognostic biomarkers in patients with head and neck squamous cell carcinomas.

Verena SailerArthur CharpentierJoern DietrichTimo J VogtAlina FranzenFriedrich BootzDimo DietrichAndreas Schroeck

Published in: PloS one (2018)

Methylation status of PITX1 and even more so of lincRNA C5orf66-AS1 is a promising prognostic biomarker in HNSCC, in particular for HPV-negative patients. Further prospective evaluation is warranted.

Keyphrases

long non coding rna
dna methylation
squamous cell
poor prognosis
end stage renal disease
high grade
genome wide
newly diagnosed
chronic kidney disease
ejection fraction
gene expression
prognostic factors
cervical cancer screening