Biological and phytochemical characterization of Phragmanthera regularis (Loranthaceae) from Ethiopia.
Abraham YirguYalemtsehay MekonnenAmelework EyadoAlessia StaropoliFrancesco VinalePublished in: Natural product research (2022)
Phragmanthera regularis is a hemi-parasitic shrub. It is known for treating various health ailments. The aim of this study was to evaluate the antimicrobial activity, toxicity, and chemical characterization of the leaf extracts of P regularis collected from the Schinus molle host plant in Ethiopia. The antimicrobial properties of crude extracts obtained with chloroform, ethyl acetate, methanol, and water solvents were assayed against Escherichia coli , Staphylococcus aureus , and Pseudomonas aeruginosa. The methanol extract significantly inhibited the growth of S. aureus, E. coli and P. aeruginosa were resistant to any of these solvent extracts. The methanol extract was tested at 175, 550, and 2000 mg/kg body weight doses in white mice and did not reveal any toxicity. The LC-MS qTOF analysis detected flavonoids, phenolic acids, and alkaloids in the crude methanol extract. Further study is needed to investigate the effectiveness of these compounds against S. aureus .
Keyphrases
- staphylococcus aureus
- escherichia coli
- oxidative stress
- body weight
- pseudomonas aeruginosa
- carbon dioxide
- ionic liquid
- randomized controlled trial
- systematic review
- biofilm formation
- cystic fibrosis
- anti inflammatory
- metabolic syndrome
- genome wide
- gene expression
- dna methylation
- ms ms
- single cell
- skeletal muscle
- health information
- klebsiella pneumoniae
- insulin resistance
- acinetobacter baumannii
- cell wall