Hyperlipidaemia elicits an atypical, T helper 1-like CD4 + T-cell response: a key role for very low-density lipoprotein.

Bram W van OsWinnie G VosLaura A BosmansClaudia M van TielSanne C LithMyrthe S den ToomLinda BeckersJohannes H M LevelsSuzanne A E van WouwNoam ZelcerEsther A ZaalCelia R BerkersChris H A van der LestJ Bernd HelmsChristian WeberDorothee AtzlerMenno P J de WintherJeroen BaardmanEsther Lutgens

Published in: European heart journal open (2023)

Hyperlipidemia, and especially its VLDL component induces an atypical Th1 response in CD4+ T cells. Underlying mechanisms include CD36 mediated uptake of VLDL, and an altered AA/DHA ratio.

Keyphrases

low density lipoprotein
high fat diet
dendritic cells
type diabetes
fatty acid
skeletal muscle
immune response
nk cells