Reversed Lipid-Based Nanoparticles Dispersed in Iodized Oil for Transarterial Chemoembolization.
Liao ShenYadan ZhangJinlong ZhangTao WangHaiyan LiYongan WangDongqin QuanPublished in: ACS applied materials & interfaces (2019)
Transarterial chemoembolization (TACE) is a promising treatment for patients suffering from unresectable liver malignancy. A coarse emulsion of doxorubicin solution and iodized oil is widely used in clinical practice. However, this coarse emulsion lacks sufficient physical stability and can split into water and oil very quickly. Furthermore, most chemotherapeutics are quickly released into systematic circulation, causing serious adverse effects. In this study, we aimed to prepare reversed lipid-based nanoparticles (RLBNs) dispersed in iodized oil as nanocarriers for the delivery of hydrophilic chemotherapeutics. Unlike a simple mixture of drug solution and oil, RLBN is a homogenous system and possesses a hydrophobic nanostructure that has high dispersibility in oils. Hydrophilic chemotherapeutics were entrapped in the polar core juxtaposed by highly biocompatible lipid materials, such as egg phospholipids. A sustained drug-release profile was observed in both in vitro and in vivo pharmacokinetics studies. The results of computed tomography showed that RLBN-doxorubicin-iodized oil could remain in the tumor region for more than 14 days and that the growth of tumors was effectively suppressed. Thus, the current results suggest that RLBN is a promising drug delivery system and is compatible with TACE treatment.
Keyphrases
- fatty acid
- drug release
- drug delivery
- computed tomography
- radiofrequency ablation
- end stage renal disease
- clinical practice
- cancer therapy
- chronic kidney disease
- ejection fraction
- molecular dynamics simulations
- emergency department
- ionic liquid
- physical activity
- peritoneal dialysis
- prognostic factors
- liver metastases
- contrast enhanced
- pet ct
- solid state
- drug induced
- solid phase extraction
- electronic health record
- rectal cancer