The type III secretion system facilitates systemic infections of Pseudomonas aeruginosa in the clinic.
Tiantian WuZhenchuan ZhangTong LiXu DongDan WuLixia ZhuKaijin XuYing ZhangPublished in: Microbiology spectrum (2023)
ST463 has spread rapidly in East China and is highly resistant to β-lactams. Given the poor clinical outcome caused by this phenotype, detailed information regarding its decisive virulence genes and factors affecting virulence expression needs to be deciphered. Here, we demonstrate that the T3SS effector ExoU has toxic effects on mammalian cells and is required for virulence in the murine bloodstream infection model. Moreover, a functional downstream SpcU is required for ExoU secretion and cytotoxicity. This work highlights the potential role of ExoU in the pathogenesis of disease and provides a new perspective for further research on the development of new antimicrobials with antivirulence ability.
Keyphrases
- pseudomonas aeruginosa
- type iii
- biofilm formation
- cystic fibrosis
- escherichia coli
- staphylococcus aureus
- antimicrobial resistance
- acinetobacter baumannii
- poor prognosis
- primary care
- regulatory t cells
- candida albicans
- klebsiella pneumoniae
- risk assessment
- immune response
- gene expression
- dna methylation
- health information
- transcription factor
- bioinformatics analysis