miR-27a induced by colon cancer cells in HLECs promotes lymphangiogenesis by targeting SMAD4.

Qi XuJin-Lu TongChen-Peng ZhangQian XiaoXiao-Lin LinXiu-Ying Xiao

Published in: PloS one (2017)

Our data indicated that colon cancer cell induced the expression of miR-27a in HLECs, which promoted lymphangiogenesis by targeting SMAD4. Our finding implicated miR-27a as a potential target for new anticancer therapies in colon cancer.

Keyphrases

cell proliferation
long non coding rna
long noncoding rna
poor prognosis
epithelial mesenchymal transition
transforming growth factor
electronic health record
signaling pathway