Hepatic CREBZF couples insulin to lipogenesis by inhibiting insig activity and contributes to hepatic steatosis in diet-induced insulin-resistant mice.

Feifei ZhangZhimin HuGaopeng LiShaofeng HuoFengguang MaAoyuan CuiYaqian XueYamei HanQi GongJing GaoHua BianZhuoxian MengHaifu WuGang LongYi TanYan ZhangXu LinXin GaoAimin XuYu Li

Published in: Hepatology (Baltimore, Md.) (2018)

These findings uncover an unexpected mechanism that couples changes in extracellular hormonal signals to hepatic lipid homeostasis; disrupting CREBZF function may have the therapeutic potential for treating fatty liver disease and insulin resistance. (Hepatology 2018).

Keyphrases

high fat diet induced
type diabetes
insulin resistance
glycemic control
polycystic ovary syndrome
intimate partner violence
adipose tissue
high fat diet
fatty acid
signaling pathway
metabolic syndrome
skeletal muscle