Decreased DNA Methylation of RGMA is Associated with Intracranial Hypertension After Severe Traumatic Brain Injury: An Exploratory Epigenome-Wide Association Study.
Dongjing LiuBenjamin E ZusmanJohn R ShafferYunqi LiAnnie I ArockiarajShuwei LiuDaniel E WeeksShashvat M DesaiPatrick M KochanekAva M PuccioDavid O OkonkwoYvette P ConleyRuchira Menka JhaPublished in: Neurocritical care (2022)
We report a novel potential relationship between intracranial hypertension after TBI and an acute, nonsustained reduction in DNA methylation at cg22111818 in the RGMA gene. To our knowledge, this is the largest EWAS in severe TBI. Our findings are further strengthened by previous findings that RGMA modulates axonal repair in other central nervous system disorders, but a role in intracranial hypertension or TBI has not been previously identified. Additional work is warranted to validate and extend these findings, including assessment of its possible role in risk stratification, identification of novel druggable targets, and ultimately our ability to personalize therapy in TBI.
Keyphrases
- severe traumatic brain injury
- dna methylation
- traumatic brain injury
- blood pressure
- genome wide
- optic nerve
- gene expression
- mild traumatic brain injury
- healthcare
- copy number
- spinal cord injury
- liver failure
- arterial hypertension
- respiratory failure
- mesenchymal stem cells
- cerebrospinal fluid
- cell therapy
- transcription factor
- replacement therapy