Impaired N-linked glycosylation of uptake and efflux transporters in human non-alcoholic fatty liver disease.

John D ClarkePetr NovakApril D LakeRhiannon N HardwickNathan J Cherrington

Published in: Liver international : official journal of the International Association for the Study of the Liver (2017)

These data suggest that the loss of glycosylation of key uptake and efflux transporters in humans NASH may influence transporter function and contribute to altered drug disposition observed in NASH.

Keyphrases

endothelial cells
electronic health record
induced pluripotent stem cells
pluripotent stem cells
big data
liver fibrosis
emergency department
machine learning
drug induced
deep learning