Novel Calcium-Binding Ablating Mutations Induce Constitutive RET Activity and Drive Tumorigenesis.

Junya Tabata Takashi Nakaoku Mitsugu Araki Ryunosuke Yoshino Shinji Kohsaka Ayaka Otsuka Masachika Ikegami Ayako Ui Shin-Ichiro Kanno Keiko Miyoshi Shigeyuki Matsumoto Yukari Sagae Akira Yasui Masakazu Sekijima Hiroyuki Mano Yasushi Okuno Aikou Okamoto Takashi Kohno

Published in: Cancer research (2022)

Comprehensive proteogenomic and in silico analyses of a vast number of VUSs identify a novel set of oncogenic and druggable mutations in the well-characterized RET oncogene.

Keyphrases

molecular docking
transcription factor
binding protein