Coordinated changes in gene expression kinetics underlie both mouse and human erythroid maturation.
Melania BarileIvan Imaz-RosshandlerIsabella InzaniShila GhazanfarJennifer NicholsJohn C MarioniCarolina GuibentifBerthold GöttgensPublished in: Genome biology (2021)
By identifying a limitation of the current velocity framework coupled with in vivo analysis of mutant cells, we reveal a coordinated step-change in gene expression kinetics during erythropoiesis, with likely implications for many other differentiation processes.