Our findings indicate the involvement of dysregulated TET2 expression in neovascularization by regulating the promoter methylation and transcription of downstream genes (notably ECM1), eventually leading to PDR. The TET2-induced hypomethylation of downstream gene promoters represents a potential therapeutic target and offers a novel perspective on the mechanism underlying neovascularization in PDR.
Keyphrases
- diabetic retinopathy
- genome wide
- optical coherence tomography
- dna methylation
- transcription factor
- genome wide identification
- poor prognosis
- extracellular matrix
- gene expression
- high glucose
- diabetic rats
- copy number
- vascular endothelial growth factor
- oxidative stress
- risk assessment
- binding protein
- genome wide analysis
- bioinformatics analysis
- stress induced