Sudden spinal hemorrhage in a pediatric case with total body irradiation-induced cavernous hemangioma.
Takashi MikamiItaru KatoFumihito NozakiKatsutsugu UmedaTatsuya KamitoriKeiji TasakaHideto OgataHidefumi HiramatsuYoshiki ArakawaSouichi AdachiPublished in: Pediatric blood & cancer (2018)
Compared to cerebral radiation-induced cavernous hemangiomas (RICHs), little is known about intraspinal RICHs. A 13-year-old male suddenly developed symptomatic spinal hemorrhage eight years after hematopoietic stem cell transplantation using a total body irradiation (TBI) based myeloablative regimen. A solitary small hemangioma was detected on follow-up T2 star weighted magnetic resonance imaging of the spine. His neurological symptoms gradually improved with supportive treatment and rehabilitation, although he experienced rebleeding 2 years later. Intraspinal RICH is very rare but should be recognized as a possible late adverse effect in pediatric patients who received TBI.
Keyphrases
- radiation induced
- traumatic brain injury
- magnetic resonance imaging
- radiation therapy
- spinal cord
- contrast enhanced
- severe traumatic brain injury
- mild traumatic brain injury
- magnetic resonance
- high glucose
- stem cell transplantation
- computed tomography
- acute myeloid leukemia
- diabetic rats
- subarachnoid hemorrhage
- cerebral ischemia
- drug induced
- emergency department
- low dose
- oxidative stress
- depressive symptoms
- combination therapy
- blood brain barrier
- replacement therapy