Real-world use and outcomes of dolutegravir-containing antiretroviral therapy in HIV and tuberculosis co-infection: a site survey and cohort study in sub-Saharan Africa.
Matthew L RomoEllen BrazierDominique Mahambou-NsondéReneé De WaalChristine Wiltshire SekaggyaCleophas ChimbeteteWinnie R MuyindikeGad MurenziCordelia KunzekwenyikaThierry TiendrebeogoJosephine A MuhairwePatricia LeloAnastase DzudieChristella TwizereIdiovino RafaelOliver Chukwujekwu EzechiLameck DieroMarcel YotebiengLukas FennerKara K Wools-KaloustianN Sarita ShahDenis Nashnull nullPublished in: Journal of the International AIDS Society (2022)
At a programmatic level, dolutegravir was being widely prescribed in sub-Saharan Africa for people with HIV and tuberculosis co-infection with a dose adjustment for the drug-drug interaction with rifampicin. Despite this more complex regimen, our cohort study revealed that dolutegravir did not negatively impact viral suppression.