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Thrombin modifies growth, proliferation and apoptosis of human colon organoids: a protease-activated receptor 1- and protease-activated receptor 4-dependent mechanism.

Morgane SébertAlexandre Denadai-SouzaMuriel QuarantaClaire Racaud-SultanSophie ChabotPhilippe LluelNicolas MonjotinLaurent AlricGuillaume PortierSylvain KirzinDelphine BonnetAudrey FerrandNathalie Vergnolle
Published in: British journal of pharmacology (2018)
Overall, our data suggest that the presence of thrombin in the vicinity of human colon epithelial cells favours their maturation at the expense of their regenerative capacities. Our data point to thrombin and its two receptors PAR1 and PAR4 as potential molecular targets for epithelial repair therapies.
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