Loss of expression of MLH1 in non-dysplastic crypts is a harbinger of neoplastic progression in sessile serrated adenomas/polyps.

Masato YozuMarina KemOdise CenajMari A Mino-KenudsonRobert D OdzeJoseph Misdraji

Published in: Histopathology (2019)

Our results suggest that loss of MLH1 expression in non-dysplastic crypts in SSAs precedes the development of MLH1-deficient dysplasia and adenocarcinoma, and may be a biomarker of an advanced serrated polyp even in the absence of dysplasia.

Keyphrases

poor prognosis
squamous cell carcinoma
binding protein
long non coding rna
radiation therapy
locally advanced