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Gut microbiota maturation during early human life induces enterocyte proliferation via microbial metabolites.

Michael W DoughertyOleksandr KudinMarcus MühlbauerJosef NeuRaad Z GharaibehChristian Jobin
Published in: BMC microbiology (2020)
Our findings indicate that microbial metabolites from the more diverse gut microbiome associated with pre-term infants facilitate stem cell proliferation. Therefore, perturbations of the pre-term microbiota may impair intestinal homeostasis.
Keyphrases
  • cell proliferation
  • ms ms
  • microbial community
  • preterm infants
  • endothelial cells
  • gestational age
  • signaling pathway
  • cell cycle
  • induced pluripotent stem cells
  • pluripotent stem cells
  • pi k akt
  • preterm birth