Type 2 diabetes is associated with impaired jejunal enteroendocrine GLP-1 cell lineage in human obesity.

Céline OsinskiLéa Le GléauChristine PoitouJuan de Toro-MartinLaurent GenserMagali FradetHédi Antoine SoulaArmelle LeturqueCorinne BlugeonLaurent JourdrenEdwige Ludiwyne HubertKarine Clement Patricia Serradas Agnès Ribeiro

Published in: International journal of obesity (2005) (2020)

These results highlight that the transcriptomic signature of EEC discriminate obese subjects according to their diabetic status. Furthermore, type 2 diabetes is associated with reduced GLP-1 cell differentiation and proglucagon maturation leading to low GLP-1-cell density in human obesity. These mechanisms could account for the decrease plasma GLP-1 observed in metabolic diseases.

Keyphrases

type diabetes
single cell
insulin resistance
endothelial cells
weight loss
metabolic syndrome
glycemic control
rna seq
cardiovascular disease
induced pluripotent stem cells
pluripotent stem cells
adipose tissue
high fat diet induced
stem cells
bariatric surgery
bone marrow
mesenchymal stem cells
obese patients