Inhibition of fibroblast growth factor-inducible 14 attenuates experimental tubulointerstitial fibrosis and profibrotic factor expression of proximal tubular epithelial cells.

Mai LuoMengmeng LiuWei LiuXiao CuiSiyue ZhaiHanjiang GuHuixia WangKunyi WuWen ZhangKe LiYumin Xia

Published in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2021)

In conclusion, TWEAK/Fn14 signals contributed to tubulointerstitial fibrosis by acting on proximal tubular epithelial cells. Fn14 inhibition might be a therapeutic strategy for protecting against renal interstitial fibrosis.

Keyphrases

poor prognosis
liver fibrosis
high glucose
binding protein
endothelial cells