What Does PET Imaging Bring to Neuro-Oncology in 2022? A Review.
Jules Tianyu Zhang-YinAntoine GirardMarc BertauxPublished in: Cancers (2022)
PET imaging is being increasingly used to supplement MRI in the clinical management of brain tumors. The main radiotracers implemented in clinical practice include [ 18 F]FDG, radiolabeled amino acids ([ 11 C]MET, [ 18 F]FDOPA, [ 18 F]FET) and [ 68 Ga]Ga-DOTA-SSTR, targeting glucose metabolism, L-amino-acid transport and somatostatin receptors expression, respectively. This review aims at addressing the current place and perspectives of brain PET imaging for patients who suffer from primary or secondary brain tumors, at diagnosis and during follow-up. A special focus is given to the following: radiolabeled amino acids PET imaging for tumor characterization and follow-up in gliomas; the role of amino acid PET and [ 18 F]FDG PET for detecting brain metastases recurrence; [ 68 Ga]Ga-DOTA-SSTR PET for guiding treatment in meningioma and particularly before targeted radiotherapy.
Keyphrases
- pet imaging
- amino acid
- pet ct
- positron emission tomography
- brain metastases
- clinical practice
- small cell lung cancer
- poor prognosis
- magnetic resonance imaging
- computed tomography
- cancer therapy
- high grade
- palliative care
- white matter
- radiation therapy
- radiation induced
- squamous cell carcinoma
- locally advanced
- combination therapy
- binding protein
- tyrosine kinase
- long non coding rna
- neuroendocrine tumors