Docosahexaenoic acid normalizes QT interval in long QT type 2 transgenic rabbit models in a genotype-specific fashion.
Alessandro CastiglioneTibor HornyikEike M WülfersLucilla GiammarinoIask EdlerJessica J JowaisMarina RiederStefanie Perez-FelizGideon KorenZsuzsanna BőszeAndrás VarróManfred ZehenderMichael BrunnerChristoph BodeSara I LiinHans Peter LarssonIstván BaczkóKatja E OdeningPublished in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2021)
Docosahexaenoic acid exerts a genotype-specific beneficial shortening/normalizing effect on QTc and APD75 and reduces pro-arrhythmia markers STVQT and AP triangulation through activation of IKs in LQT2 rabbits but has no effects if either α- or β-subunits to IKs are functionally impaired. Docosahexaenoic acid could represent a new genotype-specific therapy in LQT2.