Antiperistaltic effect and safety of l-menthol oral solution on gastric mucosa for upper gastrointestinal endoscopy in Chinese patients: Phase III, multicenter, randomized, double-blind, placebo-controlled study.

Fandong MengWenyan LiFachao ZhiZhaoshen LiZhanxiong XueShuixiang HeWeifeng ChenYingxuan ChenXiangbin XingChen YaoYongdong WuShutian Zhang

Published in: Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society (2021)

During upper GI endoscopy, a single dose of l-menthol solution (160 mg) sprayed on the gastric mucosa significantly attenuated gastric peristalsis versus placebo, thereby improving the visual stability without any safety concerns.

Keyphrases

double blind
phase iii
placebo controlled
clinical trial
phase ii
open label
study protocol
small bowel
randomized controlled trial