Ulcerative colitis, Crohn's disease, and irritable bowel syndrome have different profiles of extracellular matrix turnover, which also reflects disease activity in Crohn's disease.
Joachim Høg MortensenTina Manon-JensenMichael Dam JensenPer HägglundLone Gabriels KlingeJens KjeldsenAleksander KragMorten Asser KarsdalAnne-Christine Bay-JensenPublished in: PloS one (2017)
ECM fragments of tissue remodelling in IBD affect UC and CD differently, and may aid in differentiating IBD from IBS (EL-NE, BGM, Pro-C5), and UC from CD patients (BGM, VICM). Formation of type V collagen is related to the level of inflammation in CD and may reflect disease activity in CD.
Keyphrases
- disease activity
- rheumatoid arthritis
- systemic lupus erythematosus
- extracellular matrix
- rheumatoid arthritis patients
- irritable bowel syndrome
- ankylosing spondylitis
- ulcerative colitis
- juvenile idiopathic arthritis
- nk cells
- oxidative stress
- ejection fraction
- newly diagnosed
- magnetic resonance imaging
- prognostic factors
- body composition
- contrast enhanced
- patient reported