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Response Type and Host Species may be Sufficient to Predict Dose-Response Curve Shape for Adenoviral Vector Vaccines.

John BenestSophie RhodesSara AfroughThomas EvansRichard G White
Published in: Vaccines (2020)
Vaccine dose-response curves can follow both saturating and peaking shapes. Dose-response curves for adenoviral vector vaccines have not been systematically described. In this paper, we explore the dose-response shape of published adenoviral animal and human studies. Where data were informative, dose-response was approximately five times more likely to be peaking than saturating. There was evidence that host species and response type may be sufficient for prediction of dose-response curve shape. Dose-response curve shape prediction could decrease clinical trial costs, accelerating the development of life-saving vaccines.
Keyphrases
  • clinical trial
  • endothelial cells
  • randomized controlled trial
  • electronic health record
  • big data
  • phase ii
  • induced pluripotent stem cells
  • data analysis
  • deep learning
  • artificial intelligence
  • placebo controlled