Burden of malaria in pregnancy among adolescent girls compared to adult women in 5 sub-Saharan African countries: A secondary individual participant data meta-analysis of 2 clinical trials.
Clara Pons-DuranGhyslain Mombo-NgomaEusebio MaceteMeghna DesaiMwaka A KakolwaRella Zoleko-ManegoSmaïla OuédragouValérie BriandAnifa ValáAbdunoor M KabanywanyiPeter OumaAchille MassougbodjiEsperança SeveneMichel CotJohn J AponteAlfredo Gabriel Mayor AparicioLaurence SlutskerMichael RamharterClara MenéndezRaquel GonzalezPublished in: PLoS medicine (2022)
In this study, we observed that adolescent girls in sub-Saharan Africa (SSA) are more prone to experience clinical malaria episodes during pregnancy and have peripheral malaria and placental infection at delivery than adult women. Moreover, to the best of our knowledge, for the first time this study disaggregates figures and stratifies analyses by HIV infection. Similar associations were found for both HIV-infected and uninfected women, although those for HIV-infected participants were not statistically significant. Our finding suggests that adolescent girls may benefit from targeted malaria prevention strategies even before they become pregnant.
Keyphrases
- hiv infected
- antiretroviral therapy
- plasmodium falciparum
- polycystic ovary syndrome
- pregnancy outcomes
- clinical trial
- pregnant women
- healthcare
- human immunodeficiency virus
- randomized controlled trial
- cervical cancer screening
- insulin resistance
- hepatitis c virus
- electronic health record
- big data
- skeletal muscle
- preterm birth
- young adults
- study protocol
- phase ii
- placebo controlled