MicroRNA 429 regulates MMPs expression by modulating TIMP2 expression in colon cancer cells and inflammatory colitis.

Seol-Hee HanJi-Su MoKi-Jung YunSoo Cheon Chae

Published in: Genes & genomics (2024)

Our findings suggest that the expression of endogenous MIR429 was reduced in human CRC tissues and colitis, leading to upregulation of its target gene TIMP2. The upregulation of TIMP2 by decreased MIR429 expression in CRC tissues and inflamed tissues suggests that it may affect extracellular matrix (ECM) remodeling through downregulation of MMPs. Therefore, MIR429 may have therapeutic value for human CRC and colitis.

Keyphrases

poor prognosis
long non coding rna
cell proliferation
extracellular matrix
endothelial cells
gene expression
signaling pathway
long noncoding rna
binding protein
oxidative stress
ulcerative colitis
copy number
genome wide