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Ethaninidothioic acid (R5421) is not a selective inhibitor of platelet phospholipid scramblase activity.

Sarah Louise Millington-BurgessArkadiusz M BonnaTaufiq RahmanMatthew Thomas Harper
Published in: British journal of pharmacology (2020)
R5421 is not a selective inhibitor of platelet scramblase activity. We have identified the pesticide thiodicarb, which had similar effects on platelet function to R5421 as well as additional disruption of Ca2+ signalling which may underlie some of thiodicarb's toxicity.
Keyphrases
  • oxidative stress
  • fatty acid
  • protein kinase