High-Plex Predictive Marker Discovery for Melanoma Immunotherapy-Treated Patients Using Digital Spatial Profiling.

Maria I TokiChristopher R MerrittPok Fai WongJames W SmithyHarriet M KlugerKonstantinos N SyrigosGiang T OngSarah E WarrenJoseph M BeechemDavid L Rimm

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

DSP technology shows high concordance with QIF and validates based on both regression and outcome assessment. Using the high-plex capacity, we found a series of expression patterns associated with outcome, including that the expression of PD-L1 in macrophages is associated with response.

Keyphrases

poor prognosis
end stage renal disease
newly diagnosed
chronic kidney disease
ejection fraction
small molecule
binding protein
peritoneal dialysis
high throughput
patient reported outcomes