Deficiency of PTEN and CDKN2A Tumor-Suppressor Genes in Conventional and Chondroid Chordomas: Molecular Characteristics and Clinical Relevance.

Chenlong YangJianjun SunLei YongChen LiangTie LiuYulun XuJun YangXiaoguang Liu

Published in: OncoTargets and therapy (2020)

Our findings delineated the genetic landscape and expression of PTEN and CDKN2A in chordomas. PTEN expression may serve as a prognostic and predictive biomarker for chordomas.

Keyphrases

poor prognosis
cell proliferation
pi k akt
genome wide
binding protein
signaling pathway
long non coding rna
gene expression
single cell
single molecule
bioinformatics analysis