Therapeutic Benefit in Rheumatoid Cachexia Illustrated Using a Novel Primary Human Triple Cell Coculture Model.

Tracey OllewagenGareth S TarrKathryn H Myburgh Helmuth Reuter Anton D Van Staden

Published in: International journal of inflammation (2022)

Exposure of the triple coculture to RATN and RATNR serum resulted in dysregulated myoblast proliferation and growth, and ECM impairment, which was reversed by BMP-7 treatment.

Keyphrases

endothelial cells
single cell
mesenchymal stem cells
signaling pathway
cell therapy
pluripotent stem cells
extracellular matrix
combination therapy
systemic lupus erythematosus
replacement therapy
disease activity