Highly versatile SPION encapsulated PLGA nanoparticles as photothermal ablators of cancer cells and as multimodal imaging agents.
Balasubramanian SivakumarRavindran Girija AswathyRebeca Romero-AburtoTrevor MitchamKeith A MitchelYutaka NagaokaRichard R BouchardPulickel M AjayanToru MaekawaDasappan Nair SakthikumarPublished in: Biomaterials science (2018)
We have designed versatile polymeric nanoparticles with cancer cell specific targeting capabilities via aptamer conjugation after the successful encapsulation of curcumin and superparamagnetic iron oxide nanoparticles (SPIONs) inside a PLGA nanocapsule. These targeted nanocomposites were selectively taken up by tumor cells, under in vitro conditions, demonstrating the effectiveness of the aptamer targeting mechanism. Moreover, the nanocomposite potentially functioned as efficient multiprobes for optical, magnetic resonance imaging (MRI) and photoacoustic imaging contrast agents in the field of cancer diagnostics. The hyperthermic ability of these nanocomposites was mediated by SPIONs upon NIR-laser irradiation. In vitro cytotoxicity was shown by curcumin-loaded nanoparticles as well as the photothermal ablation of cancer cells mediated by the drug-encapsulated nanocomposite demonstrated the potential therapeutic effect of the nanocomposite. In short, we portray the aptamer-conjugated nanocomposite as a multimodal material capable of serving as a contrast agent for MR, photoacoustic and optical imaging. Furthermore, the nanocomposite functions as a targetable drug nanocarrier and a NIR-laser inducible hyperthermic material that is capable of ablating PANC-1 and MIA PaCa-2 cancer cell lines.
Keyphrases
- reduced graphene oxide
- drug delivery
- cancer therapy
- drug release
- gold nanoparticles
- high resolution
- photodynamic therapy
- fluorescence imaging
- carbon nanotubes
- contrast enhanced
- magnetic resonance imaging
- iron oxide nanoparticles
- visible light
- quantum dots
- magnetic resonance
- papillary thyroid
- solid phase extraction
- sensitive detection
- high speed
- computed tomography
- systematic review
- randomized controlled trial
- fluorescent probe
- chronic pain
- diffusion weighted imaging
- squamous cell carcinoma
- magnetic nanoparticles