Subclinical neurodegeneration in multiple sclerosis and neuromyelitis optica spectrum disorder revealed by optical coherence tomography.
Marco PisaFrancesco RattiMarco VabanesiMarta RadaelliSimone GuerrieriLucia MoiolaVittorio MartinelliGiancarlo ComiLetizia LeocaniPublished in: Multiple sclerosis (Houndmills, Basingstoke, England) (2019)
In MS, neuroretinal atrophy was associated with disease activity but occurred in progressive MS even when achieving NEDA-3 criteria. In NMOSD, pRNFL thinning was associated with non-ocular relapses due to a spreading of inflammatory activity. GCIPL thinning was found in all patients, supporting a primary retinal pathology targeting AQP4-rich structures.
Keyphrases
- multiple sclerosis
- disease activity
- optical coherence tomography
- rheumatoid arthritis
- systemic lupus erythematosus
- end stage renal disease
- spectrum disorder
- mass spectrometry
- rheumatoid arthritis patients
- newly diagnosed
- chronic kidney disease
- ms ms
- optic nerve
- white matter
- ejection fraction
- ankylosing spondylitis
- oxidative stress
- juvenile idiopathic arthritis
- prognostic factors
- high resolution
- drug delivery