Leucine protects bovine intestinal epithelial cells from hydrogen peroxide-induced apoptosis by alleviating oxidative damage.

Huiling MaoYanfang ZhangWenwen JiYan YunXiaoshi WeiYanjun CuiChong Wang

Published in: Journal of the science of food and agriculture (2022)

These results indicate that Leu promotes the relative expression of antioxidant enzymes (SOD2, CAT and GPx1) and phase II detoxification enzymes (HO-1) by upregulating nuclear Nrf2 and activating the Nrf2 signaling pathway, thus enhancing the antioxidant capacity of cells. © 2022 Society of Chemical Industry.

Keyphrases

induced apoptosis
hydrogen peroxide
oxidative stress
signaling pathway
phase ii
pi k akt
clinical trial
open label
nitric oxide
endoplasmic reticulum stress
poor prognosis
epithelial mesenchymal transition
placebo controlled
binding protein
long non coding rna
cell proliferation
cell death
study protocol