The Lack of Alterations in Metabolites in the Medial Prefrontal Cortex and Amygdala, but Their Associations with Autistic Traits, Empathy, and Personality Traits in Adults with Autism Spectrum Disorder: A Preliminary Study.
Yukihiko ShirayamaKazuki MatsumotoFumio OsoneAkira HaraSiqing GuanSayo HamataniKatsumasa MuneokaKoichi SatoAkihiro OkadaTokuzou YokokawaPublished in: Journal of autism and developmental disorders (2022)
Proton magnetic resonance spectroscopy ( 1 H-MRS) has shown inconsistent alterations in brain metabolites of adults with autism spectrum disorder (ASD). We investigated brain metabolites in the medial prefrontal cortex and amygdala of 24 drug-naive adults with ASD and no intellectual disability and 24 non-ASD control subjects, using 3 T 1 H-MRS. Adults with ASD showed no significant differences from control in glutamate, glutamate plus glutamine, N-acetylaspartate, glycerophosphorylcholine plus phosphorylcholine, creatine plus phosphocreatine, or myo-inositol in either region. However, ASD subjects did show significant correlations of localized brain metabolites with autistic traits, empathy deficits, and personality traits using the Autism-Spectrum Quotient, Questionnaire of Cognitive and Affective Empathy, Interpersonal Reactivity Index, and NEO Personality Inventory-Revised. These findings should be taken as preliminary or exploratory.
Keyphrases
- prefrontal cortex
- autism spectrum disorder
- intellectual disability
- resting state
- ms ms
- attention deficit hyperactivity disorder
- functional connectivity
- white matter
- traumatic brain injury
- genome wide
- cerebral ischemia
- psychometric properties
- bipolar disorder
- cross sectional
- dna methylation
- working memory
- atomic force microscopy
- adverse drug
- drug induced