Salmonella enterica Serovar Typhimurium Interacts with CD209 Receptors To Promote Host Dissemination and Infection.
Chenglin YeQiao LiXinyi LiChae Gyu ParkYingxia HeYingmiao ZhangBicong WuYing XueKun YangYin LvXiao-Ling YingHong-Hui DingHuahua CaiAyman Ahmad AlkraiemOlivia NjiriJohn TemboHong-Ping HuangAn-Yi LiJianping GongJichao QinBing ChengXiang WeiZiyong SunShu-Sheng ZhangPei ZhangGuo-Xing ZhengWei LiBiao KanMeiying YanXiamu XidingXixiang HuoYingchun ZengHua PengYangxin FuJohn D KlenaMikael SkurnikLing-Yu JiangTie ChenPublished in: Infection and immunity (2019)
Salmonella enterica serovar Typhimurium, a Gram-negative bacterium, can cause infectious diseases ranging from gastroenteritis to systemic dissemination and infection. However, the molecular mechanisms underlying this bacterial dissemination have yet to be elucidated. A study indicated that using the lipopolysaccharide (LPS) core as a ligand, S Typhimurium was able to bind human dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (hCD209a), an HIV receptor that promotes viral dissemination by hijacking antigen-presenting cells (APCs). In this study, we showed that S Typhimurium interacted with CD209s, leading to the invasion of APCs and potentially the dissemination to regional lymph nodes, spleen, and liver in mice. Shielding of the exposed LPS core through the expression of O-antigen reduces dissemination and infection. Thus, we propose that similar to HIV, S Typhimurium may also utilize APCs via interactions with CD209s as a way to disseminate to the lymph nodes, spleen, and liver to initiate host infection.
Keyphrases
- listeria monocytogenes
- lymph node
- gram negative
- antiretroviral therapy
- inflammatory response
- infectious diseases
- hiv positive
- hiv infected
- dendritic cells
- human immunodeficiency virus
- multidrug resistant
- hepatitis c virus
- poor prognosis
- hiv aids
- toll like receptor
- sars cov
- endothelial cells
- hiv testing
- induced apoptosis
- binding protein
- type diabetes
- metabolic syndrome
- oxidative stress
- cystic fibrosis
- men who have sex with men
- long non coding rna
- neoadjuvant chemotherapy
- pseudomonas aeruginosa
- endoplasmic reticulum stress
- cell adhesion
- pi k akt