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BCL-3 expression promotes colorectal tumorigenesis through activation of AKT signalling.

Bettina C UrbanTracey J CollardCatherine J EagleSamantha L SouthernAlexander GreenhoughMaryam Hamdollah-ZadehAnil GhoshRichard PoulsomChristos ParaskevaAndrew SilverAnn C Williams
Published in: Gut (2015)
Our study helps to unravel the mechanism by which BCL-3 is linked to poor prognosis in colorectal cancer; we suggest that targeting BCL-3 activity represents an exciting therapeutic opportunity potentially increasing the sensitivity of tumour cells to conventional therapy.
Keyphrases
  • poor prognosis
  • long non coding rna
  • induced apoptosis
  • signaling pathway
  • cell cycle arrest
  • cancer therapy
  • endoplasmic reticulum stress
  • oxidative stress
  • drug delivery
  • pi k akt
  • binding protein
  • smoking cessation