Improved health by combining dietary restriction and promoting muscle growth in DNA repair-deficient progeroid mice.
Wilbert P VermeijKhalid AlyodawiIvar van GalenJennie L von der HeideMaría B BirkisdóttirLisanne J Van't SantRutger A OzingaDaphne S J KomninosKimberly SmitYvonne M A RijksenRenata M C BrandtSander BarnhoornDick JaarsmaSathivel VaiyapuriOlli RitvosTobias B HuberOliver KretzKetan PatelPublished in: Journal of cachexia, sarcopenia and muscle (2024)
In muscle, we found synergistic effects of combining sActRIIB with DR, but not in kidney, with an overall better health in the double intervention group. Crucially, the benefits of each single intervention are not lost when administered in combination, but rather strengthened, even when sActRIIB was applied late in life, opening opportunities for translation to human.