Selective inhibition of cyclooxygenase-2 protects porcine aortic endothelial cells from human antibody-mediated complement-dependent cytotoxicity.

Pengfei ChenYanli ZhaoHanchao GaoJiabao HuangYing LuJinqi SongLizhong LinZejin LinChunpei OuHuimin SunYajing LiChangchun ZengDavid K C CooperYongqiang ZhanXuefeng DengLisha Mou

Published in: Xenotransplantation (2019)

Taken together, our data suggest that COX-2 is highly induced in PAECs by xenogenic serum and associated with human antibody-mediated complement-dependent cytotoxicity. COX-2 might be a potential therapeutic target to improve xenotransplantation.

Keyphrases

endothelial cells
high glucose
induced pluripotent stem cells
pluripotent stem cells
electronic health record
aortic valve
machine learning
nitric oxide
oxidative stress
drug induced
pulmonary arterial hypertension
data analysis
aortic dissection