Post-Operative Ileus After Digestive Surgery: Network Meta-Analysis of Pharmacological Intervention.

Etienne BuscailThibault PlanchampGuillaume Le CosquerManon BouchetJulie TheveninNicolas CarrereFabrice MuscariOlivier AbboCharlotte MaulatAriane WeylJean Pierre DuffasAntoine PhilisLaurent GhoutiCindy CanivetJean Paul MottaNathalie VergnolleCeline DeraisonJason Shourick

Published in: British journal of clinical pharmacology (2023)

Based on our meta-analysis, the two most consistent pharmacological treatments able to effectively reduce POI after abdominal surgery are prokinetics and opioid antagonists. The absence of clear superiority of one treatment over another highlights the limits of the pharmacological principles available.

Keyphrases

systematic review
randomized controlled trial
minimally invasive
chronic pain
pain management
coronary artery bypass
acute coronary syndrome
atrial fibrillation