Western-style diet in the presence of elevated circulating testosterone induces adipocyte hypertrophy without proinflammatory responses in rhesus macaques.
Benjamin J BurwitzSofiya YusovaJacob J RobinoDiana TakahashiAddie LuoOv D SlaydenCecily V BishopJon D HenneboldCharles T RobertsOleg VarlamovPublished in: American journal of reproductive immunology (New York, N.Y. : 1989) (2023)
This study shows that short-term T+WSD treatment induces weight gain, insulin resistance, and adipocyte hypertrophy, but does not have a significant effect on systemic and tissue-resident proinflammatory markers, suggesting that adipocyte hypertrophy and mild hyperandrogenemia alone are not sufficient to induce a proinflammatory response.
Keyphrases
- insulin resistance
- weight gain
- adipose tissue
- high fat diet
- metabolic syndrome
- body mass index
- skeletal muscle
- birth weight
- polycystic ovary syndrome
- fatty acid
- weight loss
- type diabetes
- high fat diet induced
- replacement therapy
- physical activity
- south africa
- glycemic control
- quality improvement
- patient safety
- combination therapy
- drug induced
- emergency medicine