Difference in driver gene expression patterns between perihilar and peripheral intrahepatic cholangiocarcinoma in an experimental mouse model.
Toshiyuki AdachiTomohiko AdachiTakehiro NakagakiShinichiro OnoMasaaki HidakaShinichiro ItoKengo KanetakaMitsuhisa TakatsukiNoriyuki NishidaSusumu EguchiPublished in: Journal of hepato-biliary-pancreatic sciences (2020)
Despite diffuse injection of oncogenic plasmid, expression of driver genes and oncogenes in ICC tumor cells differs depending on the tumor localization, resulting in changes in epithelial-mesenchymal transition, which may explain the different outcomes of patients with peripheral and perihilar ICC.
Keyphrases
- epithelial mesenchymal transition
- gene expression
- mouse model
- poor prognosis
- chemotherapy induced
- escherichia coli
- dna methylation
- transforming growth factor
- genome wide
- signaling pathway
- transcription factor
- crispr cas
- binding protein
- type diabetes
- long non coding rna
- genome wide identification
- bioinformatics analysis
- skeletal muscle
- glycemic control