Homologous recombination repair rathway and RAD54L in early-stage lung adenocarcinoma.

Shaopeng ZhengLintong YaoFasheng Li Luyu Huang Yunfang YuZenan LinHao LiJin XiaMichael LanutiHaiyu Zhou

Published in: PeerJ (2021)

HRR pathway is up-regulated in LUAD, among which the expression of RAD54L was found to be significantly differentially expressed in T1 stage tumor tissue. Patients with high expression of RAD54L were associated with worse overall survival in the TCGA cohort and validation cohort. This study suggests a potential mechanism of lung cancer progression and provide a budding prognostic factor and treatment target in early-stage LUAD.

Keyphrases

dna repair
early stage
dna damage
prognostic factors
poor prognosis
binding protein
squamous cell carcinoma
transcription factor
lymph node
long non coding rna
climate change
combination therapy
rectal cancer