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Anti-topoisomerase, but not anti-centromere B cell responses in systemic sclerosis display active, Ig-secreting cells associated with lung fibrosis.

Corrie M WortelSophie I E LiemNina Marijn van LeeuwenMaaike BoonstraCynthia M FehresLauran StögerThomas Wj HuizingaRené E M ToesJeska De Vries-BouwstraHans Ulrich Scherer
Published in: RMD open (2023)
In contrast to ACA-positive patients, ATA-positive patients show signs of recent activation of the B cell response that hallmarks this disease. The degree of activation correlates with the presence and severity of ILD, the most deleterious disease manifestation. This could explain differential responsiveness to B cell depleting therapy. The abundant and spontaneous secretion of ATA-IgG and ATA-IgA may point toward a continuously activating trigger.
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