First-in-human study of the radioligand 68Ga-N188 targeting nectin-4 for PET/CT imaging of advanced urothelial carcinoma.

Xiaojiang Duan Lei Xia Zhuochen Zhang Yanan Ren Martin G Pomper Steven P Rowe Xue-Song Li Nan Li Ning Zhang Hua Zhu Zhi Yang Xinan Sheng Xing Yang

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

A clear correlation between PET SUV value and nectin-4 expression was observed, supporting the application of 68Ga-N188 PET as a companion diagnostic tool for optimizing treatments that target nectin-4.

Keyphrases

pet ct
positron emission tomography
endothelial cells
poor prognosis
high resolution
cancer therapy
induced pluripotent stem cells
long non coding rna
binding protein
photodynamic therapy